Description

n-tert-Butyloxycarbonyl-Prolyl-Alanyl-Alanyl-Methylamide is a protected tripeptide derivative featuring a Boc-protected N-terminus and a C-terminal methylamide. This compound serves as a crucial synthetic intermediate in the development of novel peptide-based pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide synthesis, medicinal chemistry, and drug discovery programs.

Application

• Peptide Synthesis Intermediate: A key building block for the solid-phase or solution-phase synthesis of longer, more complex peptide sequences.
• Medicinal Chemistry Research: Used in the design and development of peptide analogs and peptidomimetics for therapeutic target screening.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides used in biochemical assays and diagnostic research.
• Pharmaceutical Reference Standard: Employed as a high-purity analytical standard for quality control in API (Active Pharmaceutical Ingredient) manufacturing.
• Academic & Institutional Research: Fundamental tool for studying peptide structure-activity relationships (SAR) and chemical biology.

Basic Information

Product Name	n-tert-Butyloxycarbonyl-Prolyl-Alanyl-Alanyl-Methylamide
CAS No.	103137-93-5
Molecular Formula	C₁₈H₃₁N₅O₅
Molecular Weight	397.47 g/mol
Synonyms	Boc-Pro-Ala-Ala-NHMe; Boc-L-Pro-L-Ala-L-Ala-NHMe; N-(tert-Butoxycarbonyl)-L-prolyl-L-alanyl-L-alanine methylamide; (S)-2-((S)-2-((S)-1-((tert-Butoxycarbonyl)pyrrolidine-2-carboxamido)propanamido)propanamido)propanoic acid methylamide; Boc-Pro-Ala-Ala-NHCH₃; tert-Butyl (2S)-1-[(2S)-1-[(2S)-1-(methylamino)-1-oxopropan-2-yl]amino-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our n-tert-Butyloxycarbonyl-Prolyl-Alanyl-Alanyl-Methylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, MS). A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.