Description

Renin Inhibitory Peptide, R-Pep-27 is a synthetic peptide designed to specifically inhibit the enzyme renin, a key component of the renin-angiotensin system (RAS). This targeted inhibition makes it a valuable research tool for studying cardiovascular physiology, hypertension, and renal function. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and biochemical pathway analysis.

Application

• Biomedical Research: A critical tool for in vitro and in vivo studies of the renin-angiotensin-aldosterone system (RAAS) and its role in blood pressure regulation.
• Drug Discovery & Screening: Used as a reference standard or positive control in high-throughput screening assays to identify and validate novel renin inhibitors.
• Enzyme Kinetics Studies: Employed to determine inhibitory constants (Ki, IC50) and elucidate the mechanism of action for renin inhibition.
• Cardiovascular Disease Models: Applied in animal models to investigate the pathophysiology of hypertension, heart failure, and related disorders.
• Biochemical Reagent: Serves as a specific antagonist in cell culture and tissue-based experiments to modulate RAS activity.
• Peptide Chemistry Reference: Used as a standard in analytical method development for peptide purity and stability testing.

Basic Information

Product Name	Renin Inhibitory Peptide, R-Pep-27
CAS No.	103122-78-7
Molecular Formula	C140H217N41O39
Molecular Weight	3033.5 g/mol
Synonyms	R-Pep-27; Renin Inhibitor Peptide (27-mer); H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH (This is a representative sequence; the exact sequence for R-Pep-27 is proprietary); Renin Substrate Fragment; Synthetic Renin Inhibitory Peptide; RAS Inhibitor Peptide; Angiotensinogen-derived Peptide Inhibitor
EINECS	Contact for details

Quality Control

Our Renin Inhibitory Peptide, R-Pep-27 is manufactured under strict quality protocols. Each batch is characterized using advanced analytical techniques including HPLC and mass spectrometry to ensure high purity and correct sequence integrity. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided to guarantee reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.