Description

[D-p-Cl-Phe(6),Leu(17)]-Vasoactive Intestinal Peptide Human, Porcine, Rat is a synthetic, biologically active peptide analog of Vasoactive Intestinal Peptide (VIP). This modified peptide is engineered for enhanced stability and specificity in research applications, making it a critical tool for studying neuroendocrine signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on endocrinology, immunology, and neurobiology.

Application

• Biomedical Research: Used as a potent and selective agonist/antagonist to study VIP receptor (VPAC1/VPAC2) signaling and function in vitro and in vivo.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel therapeutics for inflammatory, autoimmune, and neurological disorders.
• Physiological Studies: Investigates the role of VIP in smooth muscle relaxation, vasodilation, and secretory processes.
• Immunology Research: Explores the immunomodulatory effects of VIP on cytokine production and T-cell differentiation.
• Neuroscience: A key reagent for studying neuroprotection, circadian rhythms, and the central nervous system effects of VIP.
• Assay Development: Employed as a critical component in the development and validation of high-throughput screening (HTS) and ELISA-based assays.

Basic Information

Product Name	[D-p-Cl-Phe(6),Leu(17)]-Vasoactive Intestinal Peptide Human, Porcine, Rat
CAS No.	102805-45-8
Molecular Formula	C147H238N42O43Cl
Molecular Weight	3326.7 g/mol (approximate)
Synonyms	VIP (6-28), [D-p-Cl-Phe6, Leu17]-VIP; [D-4-Chlorophenylalanine6,Leucine17]-Vasoactive Intestinal Peptide; VIP antagonist (6-28); pCL-D-Phe6,Leu17-VIP; Vasoactive Intestinal Polypeptide fragment 6-28 analog; Modified VIP peptide; VIP receptor ligand analog
EINECS	Contact for details

Quality Control

Every batch of our high-purity peptide is manufactured under strict quality systems. Certificates of Analysis (COA) are provided, detailing comprehensive testing including HPLC purity (typically >95%), mass spectrometry (MS) confirmation, and amino acid analysis (AAA). We adhere to relevant guidelines for research-grade bioactive peptides to ensure identity, purity, and biological activity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Biological Activity	Assessed by receptor binding or functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.