Description

2-Iodo-5-(Trifluoromethyl)Phenol is a versatile halogenated phenol derivative, distinguished by its trifluoromethyl and iodine substituents. This compound is a critical synthetic intermediate valued for its ability to introduce both halogen and fluorinated aromatic motifs into complex molecular architectures. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the synthesis of advanced functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Heck) to construct biaryl and complex conjugated systems.
• Ligand and Catalyst Development: Utilized in the synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new fluorination methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-Iodo-5-(Trifluoromethyl)Phenol
CAS No.	102771-00-6
Molecular Formula	C7H4F3IO
Molecular Weight	287.01 g/mol
Synonyms	5-(Trifluoromethyl)-2-iodophenol; 2-Iodo-α,α,α-trifluoro-p-cresol; Phenol, 2-iodo-5-(trifluoromethyl)-; 2-Hydroxy-5-(trifluoromethyl)iodobenzene; 3-Iodo-4-hydroxybenzotrifluoride; 2-Iodo-5-trifluoromethylphenol; 5-Trifluoromethyl-2-iodophenol
EINECS	Contact for details

Quality Control

Our 2-Iodo-5-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.