Description

H-Gln(Trt)-OH is a protected glutamine derivative, specifically N-α-Fmoc-N-γ-trityl-L-glutamine, widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing orthogonal protection for the glutamine side chain, preventing unwanted side reactions and enabling the synthesis of complex peptides with high fidelity. This high-purity amino acid derivative is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors engaged in the development of peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of peptides and proteins.
• Pharmaceutical Intermediates: Serves as a key raw material in the production of active pharmaceutical ingredients (APIs) for peptide drugs.
• Research & Development: Used in academic and industrial R&D labs for exploring new peptide sequences, structure-activity relationships (SAR), and novel bioconjugates.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Bioconjugation: Acts as a precursor for creating peptide-based probes, tags, and linkers used in diagnostic assays and targeted drug delivery systems.
• GMP Manufacturing: Suitable for use in Good Manufacturing Practice (GMP) environments for the production of clinical-grade peptide therapeutics.

Basic Information

Item	Detail
Product Name	H-Gln(Trt)-OH
CAS No.	102747-84-2
Molecular Formula	C30H28N2O3
Molecular Weight	464.56 g/mol
Synonyms	Fmoc-Gln(Trt)-OH; N-α-Fmoc-N-γ-trityl-L-glutamine; Fmoc-L-glutamine(trityl)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid; Fmoc-Gln(Trt); N-Fmoc-N'-trityl-L-glutamine; Fmoc-Glutamine(Trt)-OH; Fmoc-Gln(Trt)
EINECS	Contact for details

Quality Control

Our H-Gln(Trt)-OH is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically meeting standards for peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, assay, and impurity profiles. We support compliance with relevant pharmacopeial guidelines and can supply material suitable for GMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.