Description

3-Methylglutarylcarnitine is a specialized acylcarnitine derivative, a key intermediate in the metabolism of leucine and other branched-chain amino acids. This compound is of significant interest in biochemical research and diagnostic applications related to inborn errors of metabolism. It serves as a critical reference standard and analytical reagent for laboratories in the pharmaceutical, clinical diagnostics, and life science research sectors.

Application

• Biochemical Research Standard: Used as a high-purity reference material for studying leucine catabolism and mitochondrial fatty acid oxidation pathways.
• Clinical Diagnostics: Essential for the calibration and validation of LC-MS/MS systems in newborn screening and the diagnosis of organic acidemias, such as 3-methylglutaconic aciduria.
• Metabolomics Studies: A vital analyte in targeted and untargeted metabolomics profiling to understand metabolic disorders and disease biomarkers.
• Pharmaceutical Development: Employed in the research and quality control of therapeutic agents targeting metabolic pathways.
• Enzyme Activity Assays: Serves as a substrate or product in enzymatic assays for acyl-CoA dehydrogenases and related enzymes.

Basic Information

Product Name	3-Methylglutarylcarnitine
CAS No.	102673-95-0
Molecular Formula	C13H23NO7
Molecular Weight	305.32 g/mol
Synonyms	(3R)-3-({[(2R)-3-Carboxy-2-hydroxypropyl]carbamoyl}methyl)-4-methyl-5-oxopentanoic acid; (R)-3-Methylglutarylcarnitine; L-3-Methylglutarylcarnitine; 3-Methylglutaryl-L-carnitine; 3-MG-carnitine; 3-Methylglutaconylcarnitine (related isomer); 3-Hydroxy-3-methylglutarylcarnitine (related metabolite)
EINECS	Contact for details

Quality Control

Our 3-Methylglutarylcarnitine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.