Description

Z-Gly-Gly-Ile-Oh is a protected tripeptide derivative, specifically a benzyloxycarbonyl (Z)-blocked precursor. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains with high fidelity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled, sequential assembly of longer, complex peptide sequences in both research and GMP manufacturing.
• Pharmaceutical Intermediate: Used in the research and development of potential therapeutic peptides targeting various metabolic and signaling pathways.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate protease specificity and function.
• Peptidomimetic Development: Serves as a starting point for creating modified peptide analogs with enhanced stability, bioavailability, or receptor affinity.
• Custom Peptide Services: A key raw material for CROs and CDMOs offering bespoke peptide synthesis for academic and industrial clients.

Basic Information

Product Name	Z-Gly-Gly-Ile-Oh
CAS No.	102601-54-7
Molecular Formula	C₁₉H₂₇N₃O₆
Molecular Weight	393.44 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]glycylglycyl-L-isoleucine; Z-Gly-Gly-L-Ile-OH; Cbz-Gly-Gly-Ile-OH; N-Carbobenzoxy-glycyl-glycyl-L-isoleucine; Benzyl N-[(2S)-1-[[2-(2-aminoacetamido)acetyl]amino]-3-methyl-1-oxopentan-2-yl]carbamate; (S)-2-((((Benzyloxy)carbonyl)amino)methyl)-4-methylpentanoic acid; Z-Gly-Gly-Ile; Cbz-Gly-Gly-L-Ile
EINECS	Contact for details

Quality Control

Our Z-Gly-Gly-Ile-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) with detailed chromatograms are provided to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Contact for details
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.