Description

5-(2-Hydroxy-3-Iodopropyl)-5-Isopropyl-2,4,6(1H,3H,5H)-Pyrimidinetrione is a specialized iodinated barbiturate derivative, a key intermediate in advanced organic synthesis. This compound matters for its unique molecular architecture, which provides a versatile scaffold for constructing complex pharmacologically active molecules. It is primarily needed by research institutions and pharmaceutical development companies focused on creating novel therapeutic agents, particularly in the fields of central nervous system (CNS) drugs and diagnostic imaging agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel barbiturate analogs and other heterocyclic compounds with potential sedative, hypnotic, or anesthetic properties.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities targeting GABAA receptors and other neurological targets.
• Radiopharmaceutical Precursor: The iodine atom provides a potential site for radioiodination (123I, 125I, 131I), making it a candidate precursor for developing diagnostic or therapeutic radiopharmaceuticals.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and biological pathways due to its modifiable hydroxy and iodopropyl groups.
• Advanced Organic Synthesis: Serves as a versatile intermediate for further functionalization, enabling the creation of libraries of complex molecules for high-throughput screening.

Basic Information

Product Name	5-(2-Hydroxy-3-Iodopropyl)-5-Isopropyl-2,4,6(1H,3H,5H)-Pyrimidinetrione
CAS No.	102585-91-1
Molecular Formula	C10H15IN2O4
Molecular Weight	354.14 g/mol
Synonyms	5-Isopropyl-5-(2-hydroxy-3-iodopropyl)barbituric acid; 5-(2-Hydroxy-3-iodopropyl)-5-(1-methylethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-(1-Methylethyl)-5-(2-hydroxy-3-iodopropyl)-2,4,6-pyrimidinetrione; Iodopropylisopropylbarbituric Acid; 5-Isopropyl-5-(3-iodo-2-hydroxypropyl)barbituric acid
EINECS	Contact for details

Quality Control

Our 5-(2-Hydroxy-3-Iodopropyl)-5-Isopropyl-2,4,6(1H,3H,5H)-Pyrimidinetrione is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and may be hygroscopic; therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.