Description

Z-Gly-Phe-Gly-Aldehyde Semicarbazone is a specialized synthetic peptide derivative, specifically a protected aldehyde semicarbazone. This compound is a crucial chemical building block and protease inhibitor precursor used in advanced biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of medicinal chemistry and proteomics for designing and synthesizing novel enzyme inhibitors.

Application

• Protease Inhibitor Synthesis: Serves as a key intermediate in the development of potent and selective inhibitors for serine and cysteine proteases.
• Medicinal Chemistry Research: Used as a scaffold or building block in drug discovery programs targeting diseases where protease activity is dysregulated.
• Bioconjugation & Probe Development: The reactive aldehyde group, protected as the semicarbazone, can be used for site-specific labeling of proteins or other biomolecules.
• Enzyme Mechanism Studies: Employed in biochemical assays to study enzyme kinetics and inhibition mechanisms.
• Pharmaceutical Intermediate: A potential precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) with protease inhibitory activity.
• Peptidomimetic Design: Facilitates the creation of peptide analogs with enhanced stability and bioavailability for therapeutic applications.

Basic Information

Product Name	Z-Gly-Phe-Gly-Aldehyde Semicarbazone
CAS No.	102579-47-5
Molecular Formula	C23H27N5O6
Molecular Weight	469.49 g/mol
Synonyms	Z-Gly-Phe-Gly-H; Z-Gly-Phe-Gly-CHO Semicarbazone; N-[(Benzyloxy)carbonyl]glycyl-L-phenylalanylglycinal Semicarbazone; Carbobenzoxy-Gly-Phe-Gly-aldehyde Semicarbazone; Z-Gly-Phe-Gly-aldehyde semicarbazone; Boc-Gly-Phe-Gly-CHO Semicarbazone (common alternate); N-CBZ-Glycyl-L-phenylalanylglycinal Semicarbazone; Protease Inhibitor Precursor Z-GFG-CHO-SC
EINECS	Contact for details

Quality Control

Our Z-Gly-Phe-Gly-Aldehyde Semicarbazone is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.