Description

1-Adamantanamine Citrate Monohydrate is a high-purity, pharmaceutically relevant salt form of amantadine, offering enhanced stability and handling properties. This compound is critical for ensuring precise formulation and consistent biological activity in advanced therapeutic applications. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development and production of antiviral and neurological medications.

Application

• Pharmaceutical Active Ingredient (API): Serves as a key intermediate or final active component in antiviral and anti-Parkinson's drug formulations.
• Neurological Research: Used in preclinical studies targeting NMDA receptors and dopaminergic pathways.
• Antiviral Agent Development: Employed in the synthesis and research of compounds active against influenza A virus and other enveloped viruses.
• Reference Standard: Acts as a certified reference material (CRM) for quality control and analytical method development in pharmacopeial testing.
• Chemical Synthesis: Utilized as a building block for creating more complex adamantane-derived molecules with tailored properties.
• Formulation Studies: Applied in the development of stable dosage forms, leveraging its citrate salt properties for improved solubility.

Basic Information

Product Name	1-Adamantanamine Citrate Monohydrate
CAS No.	102395-13-1
Molecular Formula	C10H17N · C6H8O7 · H2O
Molecular Weight	339.36 g/mol
Synonyms	Amantadine Citrate Monohydrate; 1-Adamantylamine Citrate Monohydrate; 1-Aminoadamantane Citrate Monohydrate; Adamantan-1-amine Citrate Monohydrate; Tricyclo[3.3.1.13,7]decan-1-amine Citrate Monohydrate; PK-Merz (salt form); Symmetrel (salt form)
EINECS	Contact for details

Quality Control

Our 1-Adamantanamine Citrate Monohydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and composition. Certificates of Analysis (COA) are provided, detailing results from HPLC, IR, and other pharmacopeial tests. We support compliance with cGMP, ICH Q7 guidelines, and relevant regulatory frameworks for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	4.5% - 6.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.