Description

Substance P, Cyclo(H-Glu-Phe-Phe-Gly-Leu-Met-Nh(Ch2)3-Nh-) is a synthetic cyclic peptide analog of the neuropeptide Substance P, designed for enhanced stability and specific receptor interaction. This compound is a critical research tool for studying neurokinin-1 (NK1) receptor signaling pathways, pain transmission, and inflammatory responses in both academic and pharmaceutical development settings. It is essential for researchers and developers in neuroscience, pharmacology, and drug discovery who require high-purity, well-characterized peptide ligands for receptor binding assays, functional studies, and as a reference standard.

Application

• Neuroscience Research: As a potent and selective NK1 receptor agonist/antagonist for studying pain pathways, neuroinflammation, and central nervous system disorders.
• Pharmacological Assay Development: Used as a reference standard in competitive binding assays and functional cell-based tests to screen novel drug candidates.
• Biochemical Tool Compound: Employed in signal transduction research to elucidate the role of Substance P in various physiological and pathological processes.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the preclinical development of therapies targeting the NK1 receptor.
• Academic & Institutional Research: Provides a reliable, high-purity compound for university and research institute labs focused on peptide biology and neuropharmacology.

Basic Information

Product Name	Substance P, Cyclo(H-Glu-Phe-Phe-Gly-Leu-Met-Nh(Ch2)3-Nh-)
CAS No.	102334-63-4
Molecular Formula	C41H58N8O8S
Molecular Weight	823.02 g/mol
Synonyms	Cyclo(Glutamyl-Phenylalanyl-Phenylalanyl-Glycyl-Leucyl-Methionyl-3-aminopropylamide); Cyclic Substance P analog (6-11), amide; [Cyclo6-11]Substance P; Substance P (6-11) cyclic lactam analog; NK1 receptor ligand; CAS 102334-63-4; Cyclo(H-Glu-Phe-Phe-Gly-Leu-Met-NH(CH2)3NH2)
EINECS	Contact for details

Quality Control

Our Substance P analog is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with full chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.