Description

α-(4-Aminobutyryl)Hypusine is a specialized, biologically significant derivative of the amino acid hypusine. This compound is of critical importance in biochemical research, particularly in the study of eukaryotic translation initiation and cellular growth regulation. It serves as a key intermediate and reference standard for scientists investigating post-translational modification pathways. Target users include pharmaceutical R&D teams, academic research institutions, and manufacturers of high-purity biochemical reagents.

Application

• Biochemical Research Standard: Used as a high-purity reference material in studies of hypusine biosynthesis and function.
• Enzyme Substrate Studies: Acts as a substrate for deoxyhypusine synthase (DHS) and hypusine-forming enzymes in mechanistic and kinetic assays.
• Pharmaceutical Development: Investigated as a potential precursor or target in therapeutic strategies aimed at modulating cell proliferation and protein synthesis.
• Metabolic Pathway Analysis: Employed in tracer studies to elucidate the polyamine-hypusine pathway in various cell types and disease models.
• Diagnostic Reagent Manufacturing: Utilized in the production of specialized kits and reagents for research into aging, neurobiology, and oncology.
• Academic & Institutional Research: Supports fundamental research in molecular biology, biochemistry, and cell signaling at universities and government labs.

Basic Information

Product Name	α-(4-Aminobutyryl)Hypusine
CAS No.	102202-89-1
Molecular Formula	C14H28N4O5
Molecular Weight	332.40 g/mol
Synonyms	Nε-(4-Aminobutyl)-Nε-(4-aminobutyryl)lysine; (2S)-2-Amino-6-{[(2S)-5-amino-1-{[(2S)-5-amino-1-oxopentan-2-yl]amino}-1-oxopentan-2-yl]amino}hexanoic acid; 4-Aminobutyrylhypusine; L-Hypusine, Nε-(4-aminobutyryl)-; N6-(4-Aminobutyryl)-N6-(4-aminobutyl)-L-lysine; α-(4-Aminobutyryl)hypusine
EINECS	Contact for details

Quality Control

Our α-(4-Aminobutyryl)Hypusine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.