Description

Boc-Val-Leu-Gly-Arg-Oh is a protected tetrapeptide sequence featuring a C-terminal arginine residue. This compound is a crucial synthetic intermediate in the research and development of novel bioactive peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for constructing larger peptide chains, studying enzyme-substrate interactions, and developing therapeutic candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the sequential assembly of longer, more complex peptide sequences in drug discovery.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving proteases like trypsin or thrombin due to the arginine moiety.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential therapeutic peptides targeting cardiovascular, metabolic, or oncological pathways.
• Protease Specificity Profiling: Employed to investigate the cleavage specificity and kinetics of various serine proteases.
• Custom Peptide Service: A fundamental component offered by CROs and CDMOs for producing client-specified peptide sequences for research use.
• Structure-Activity Relationship (SAR) Studies: The protected form allows for selective deprotection and modification to explore the impact of specific amino acids on biological activity.

Basic Information

Product Name	Boc-Val-Leu-Gly-Arg-Oh
CAS No.	102185-55-7
Molecular Formula	C24H46N8O7
Molecular Weight	558.68 g/mol
Synonyms	Boc-Val-Leu-Gly-Arg-OH; tert-Butyloxycarbonyl-Valyl-Leucyl-Glycyl-Arginine; N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-leucyl-glycyl-L-arginine; Boc-V-L-G-R-OH; BOC-VLGK-OH (common abbreviation); (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoic acid; BOC-L-VALYL-L-LEUCYL-GLYCYL-L-ARGININE
EINECS	Contact for details

Quality Control

Our Boc-Val-Leu-Gly-Arg-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized by advanced analytical techniques including HPLC, MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This product is hygroscopic (moisture-sensitive); allow the sealed container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 97.0%
Specific Rotation	-30° to -40° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.