Description

3-(6-Bromo-4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its brominated quinazolinone core structure. This compound is of significant value for its role as a key building block in the synthesis of complex, biologically active molecules, particularly kinase inhibitors. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including potential treatments for cancer and inflammatory diseases. Its precise chemical architecture enables targeted modifications critical for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of targeted kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Used in the development of assay probes and inhibitors for studying specific enzyme pathways and cellular mechanisms.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis and scale-up projects.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and the development of new synthetic methodologies.

Basic Information

Product Name	3-(6-Bromo-4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid
CAS No.	102118-19-4
Molecular Formula	C₁₁H₉BrN₂O₃
Molecular Weight	297.11 g/mol
Synonyms	3-(6-Bromo-4-oxo-3,4-dihydroquinazolin-3-yl)propanoic acid; 6-Bromo-3-(2-carboxyethyl)-3,4-dihydro-4-quinazolinone; 3-(6-Bromo-4-oxoquinazolin-3(4H)-yl)propionic Acid; 102118-19-4; 6-Bromoquinazolinone propanoic acid derivative; Quinazolin-4(3H)-one, 6-bromo-3-(2-carboxyethyl)-; Bromo-oxoquinazolinylpropanoic Acid
EINECS	Contact for details

Quality Control

Our 3-(6-Bromo-4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.