Description

Fmoc-D-Pipecolic Acid CAS NO 101555-63-9 is a high-purity, non-proteinogenic amino acid derivative extensively used as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled, sequential assembly of complex peptides and peptidomimetics, particularly those requiring the incorporation of the conformationally constrained D-pipecolic acid scaffold. This compound is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on creating novel therapeutic peptides, protease inhibitors, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated synthesis of custom peptides.
• Pharmaceutical Intermediate: Key building block in the research and production of peptide-based drugs and drug candidates.
• Protease Inhibitor Development: Used to synthesize inhibitors targeting various proteases, leveraging the structural properties of the pipecolic acid ring.
• Peptidomimetic Research: Incorporation into non-natural peptide analogs to enhance metabolic stability, bioavailability, and binding affinity.
• Bioconjugation and Labeling: Serves as a component in the synthesis of peptide tags, probes, and conjugates for diagnostic and research applications.
• Combinatorial Chemistry Libraries: Used to generate diverse libraries of compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-D-Pipecolic Acid
CAS No.	101555-63-9
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-D-Pip-OH; (R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-pipecolic acid; D-Pipecolic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-D-homoPro-OH; Fmoc-D-Pipecolate
EINECS	Contact for details

Quality Control

Our Fmoc-D-Pipecolic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a comprehensive Certificate of Analysis (COA). We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.