Description

Neurokinin B Tfa CAS NO 101536-55-4 is a synthetic peptide analog of the endogenous tachykinin neuropeptide, Neurokinin B, modified with a trifluoroacetate (Tfa) salt. This compound is a critical research tool for investigating the neurokinin receptor (NK3) signaling pathway, which plays a significant role in various physiological and pathological processes. It is essential for researchers and developers in the fields of neuroscience, endocrinology, and pharmaceutical discovery who require high-purity, reliable biochemicals for receptor binding studies, functional assays, and drug development programs.

Application

• Neuroscience Research: Used as a selective agonist for the NK3 receptor in studies of central and peripheral nervous system function.
• Pharmacological Assays: Critical for in vitro and ex vivo bioassays to screen and characterize potential neurokinin receptor antagonists or modulators.
• Endocrine Studies: Applied in research exploring the role of Neurokinin B in reproductive endocrinology, including puberty onset and gonadotropin-releasing hormone (GnRH) secretion.
• Drug Discovery & Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of therapeutics for conditions like schizophrenia, depression, and hormone-related disorders.
• Academic & Institutional Research: Provides a key reagent for fundamental research into tachykinin signaling pathways and their physiological implications.

Basic Information

Product Name	Neurokinin B Tfa
CAS No.	101536-55-4
Molecular Formula	C58H83N19O13S2 • xC2HF3O2
Molecular Weight	1350.55 g/mol (free base)
Synonyms	Neurokinin B Trifluoroacetate; NKB Tfa; Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 Trifluoroacetate; Tachykinin 4 (4-10), human; TAC4 (101-110) (human); H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 xTFA; NK-3 Receptor Agonist
EINECS	Contact for details

Quality Control

Every batch of Neurokinin B Tfa is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity (HPLC), peptide content, and other critical parameters relevant for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Peptide Content	≥80%
Single Impurity (HPLC)	≤1.0%
Water Content (KF)	≤8.0%
Acetate Content (HPLC)	≤10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.