Description

4-(Trifluoromethyl)-Benzenepropanamine is a versatile aromatic amine building block characterized by a propylamine side chain and a trifluoromethyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is needed by research and development chemists, process scale-up teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this valuable fluorinated motif into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of monomers for specialty polymers, coatings, and liquid crystals with unique thermal and chemical resistance properties.
• Fluorinated Compound Library: A valuable building block for medicinal chemistry and combinatorial chemistry to create diverse libraries of fluorinated compounds for high-throughput screening.

Basic Information

Product Name	4-(Trifluoromethyl)-Benzenepropanamine
CAS No.	101488-60-2
Molecular Formula	C10H12F3N
Molecular Weight	203.21 g/mol
Synonyms	3-[4-(Trifluoromethyl)phenyl]propan-1-amine; 4-(Trifluoromethyl)phenethylamine, N/A; 3-(4-Trifluoromethylphenyl)propylamine; Benzenepropanamine, 4-(trifluoromethyl)-; 1-Amino-3-(4-trifluoromethylphenyl)propane; γ-(4-Trifluoromethylphenyl)propylamine; 101488-60-2 (CAS)
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-Benzenepropanamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of cGMP and ISO 9001 standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Gravity	1.15 - 1.25 g/mL @ 20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.