Description

2-Bromo-4,6-Difluoroaniline Hydrobromide is a halogenated aniline derivative salt, serving as a critical building block in advanced organic synthesis. Its value lies in providing a reactive aromatic amine core with strategically placed bromine and fluorine substituents, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system and anti-infective applications.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the difluoro and bromo groups contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing complex azo dyes and high-performance pigments requiring halogenated aniline components.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig amination for carbon-carbon and carbon-nitrogen bond formation.
• Fluorinated Compound Library: A valuable reagent for medicinal chemistry and drug discovery programs focused on incorporating fluorine atoms to modulate potency, lipophilicity, and bioavailability.

Basic Information

Product Name	2-Bromo-4,6-Difluoroaniline Hydrobromide
CAS No.	101471-20-9
Molecular Formula	C6H5Br2F2N
Molecular Weight	308.92 g/mol
Synonyms	2-Bromo-4,6-difluoroaniline HBr; Benzenamine, 2-bromo-4,6-difluoro-, hydrobromide; 4,6-Difluoro-2-bromoaniline hydrobromide; 2-Bromo-4,6-difluoro-phenylammonium bromide; Aniline, 2-bromo-4,6-difluoro-, hydrobromide; 101471-20-9; 2-Br-4,6-F2-C6H2NH2·HBr
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,6-Difluoroaniline Hydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.