Description

(S)-1,2,3,4-Tetrahydro-5-Methoxy-n-Propyl-2-Naphthalenamine (Rotigotine) is a high-purity, non-ergoline dopamine agonist with significant pharmacological activity. This compound is critical for the development and production of advanced pharmaceutical formulations targeting central nervous system disorders. It is primarily required by pharmaceutical R&D laboratories, active pharmaceutical ingredient (API) manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in neurology and movement disorder therapeutics.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the key therapeutic agent in the formulation of dopamine agonist medications.
• Neurological Disorder Treatment: Core component in drugs for Parkinson's disease and Restless Legs Syndrome (RLS).
• Pharmaceutical Research & Development: Serves as a critical reference standard and building block in preclinical and clinical studies for novel CNS therapies.
• Transdermal Drug Delivery Systems: Used in the development of patch formulations for controlled, continuous drug delivery.
• Analytical Standard: High-purity material for use in quality control (QC) and analytical method development (HPLC, GC, MS).
• Process Chemistry & Scale-Up: Intermediate or final compound for process optimization and commercial-scale GMP manufacturing.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydro-5-Methoxy-n-Propyl-2-Naphthalenamine (Rotigotine)
CAS No.	101403-24-1
Molecular Formula	C19H25NO
Molecular Weight	283.41 g/mol
Synonyms	Rotigotine; (S)-(-)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthol; (S)-(-)-N-Propyl-5,6,7,8-tetrahydro-6-[2-(2-thienyl)ethylamino]-1-naphthol; N-0923; SPM 962; Dopamine D2/D3 Receptor Agonist; (S)-2-(N-Propyl-N-2-thienylethylamino)-5-hydroxytetralin
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydro-5-Methoxy-n-Propyl-2-Naphthalenamine (Rotigotine) is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific pharmacopeial (e.g., USP, EP) or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.