Description

4-Pyrimidinamine, 5-Chloro- (9Ci) CAS NO 101257-82-3 is a high-purity halogenated pyrimidine derivative, a crucial heterocyclic building block in advanced organic synthesis. Its primary value lies in serving as a versatile and reactive intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for API synthesis and novel compound libraries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in antiviral, anticancer, and kinase inhibitor drug discovery programs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators where the pyrimidine core is a common bioactive motif.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization (e.g., cross-coupling reactions, nucleophilic substitutions) to create diverse chemical libraries for high-throughput screening.
• Material Science: Potential intermediate in the synthesis of organic electronic materials, ligands for catalysts, and specialty polymers.
• Academic & Contract Research: Used in universities and CROs (Contract Research Organizations) for fundamental research in heterocyclic chemistry and medicinal chemistry.

Basic Information

Product Name	4-Pyrimidinamine, 5-Chloro- (9Ci)
CAS No.	101257-82-3
Molecular Formula	C4H4ClN3
Molecular Weight	129.55 g/mol
Synonyms	5-Chloropyrimidin-4-amine; 5-Chloro-4-pyrimidinamine; 4-Amino-5-chloropyrimidine; 5-Chloro-4-aminopyrimidine; 5-Chloro-4-pyrimidinylamine; 5-Chloro-pyrimidin-4-ylamine; 101257-82-3
EINECS	Contact for details

Quality Control

Our 4-Pyrimidinamine, 5-Chloro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and other relevant spectroscopic methods. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.