Description

Fmoc-Phe-Osu CAS NO 101214-43-1 is a high-purity, activated ester derivative of Fmoc-protected L-phenylalanine, specifically designed for efficient peptide synthesis. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of complex peptides and proteins, offering superior coupling efficiency and minimal racemization. It is an essential reagent for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on peptide-based therapeutics and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key activated amino acid derivative for the efficient, stepwise construction of peptide chains on resin supports.
• Pharmaceutical Intermediates: For the synthesis of active pharmaceutical ingredients (APIs) in peptide-based drugs, including hormones, antibiotics, and antiviral agents.
• Bioconjugation: Used to introduce the Fmoc-Phe moiety into proteins, antibodies, or other biomolecules for labeling, drug delivery, or structural studies.
• Combinatorial Chemistry: A vital component in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic & Industrial Research: Essential for biochemical research involving peptide structure-activity relationships (SAR) and protein engineering.
• Custom Peptide Service Providers: A standard reagent for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Phe-Osu
CAS No.	101214-43-1
Molecular Formula	C25H20N2O6
Molecular Weight	444.44 g/mol
Synonyms	Fmoc-L-phenylalanine N-hydroxysuccinimide ester; N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine N-succinimidyl ester; Fmoc-Phe-OSu; Fmoc-Phenylalanine-OSu; N-α-Fmoc-L-phenylalanine N-succinimidyl ester; (9H-Fluoren-9-ylmethoxy)carbonyl-L-phenylalanine 2,5-dioxopyrrolidin-1-yl ester; Fmoc-Phe-ONSu; Fmoc-Phe-Osu CAS 101214-43-1
EINECS	Contact for details

Quality Control

Our Fmoc-Phe-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, chiral analysis to confirm enantiomeric purity, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.