Description

Substance P, α-n-Arg(1)-ε-n-Lys(3)-Di-(Pyridoxal Phosphate)- CAS NO 101213-43-8 is a chemically modified derivative of the neuropeptide Substance P, where specific arginine and lysine residues are covalently linked to pyridoxal phosphate (PLP) moieties. This bifunctional conjugate is engineered to combine the biological signaling properties of Substance P with the coenzymatic and biochemical reactivity of vitamin B6 derivatives. It is primarily utilized in advanced biochemical research and pharmaceutical development, particularly for studies involving neurokinin receptor modulation, enzyme cofactor interactions, and targeted drug delivery systems. This compound serves as a critical tool for researchers in neuroscience, pharmacology, and medicinal chemistry.

Application

• Neuroscience Research: Investigation of Substance P receptor (NK1) signaling pathways and neuroinflammatory processes.
• Enzyme Mechanism Studies: Probing the role of pyridoxal phosphate as a cofactor in enzymatic reactions, including transaminases and decarboxylases.
• Targeted Therapeutic Conjugates: Serving as a prototype for designing bifunctional drug candidates that target specific neuronal populations.
• Biochemical Probe Development: Creation of fluorescent or affinity-tagged probes for protein interaction studies and cellular imaging.
• Pharmaceutical R&D: Pre-clinical evaluation of novel compounds for pain management, neurodegenerative diseases, and psychiatric disorders.
• Metabolic Pathway Analysis: Studying the intersection of neuropeptide activity and vitamin B6-dependent metabolism in cell models.

Basic Information

Product Name	Substance P, α-n-Arg(1)-ε-n-Lys(3)-Di-(Pyridoxal Phosphate)- CAS NO 101213-43-8
CAS No.	101213-43-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Substance P-PLP Conjugate; Arg(1),Lys(3)-Bis(pyridoxal phosphate)-Substance P; PLP-Modified Substance P; Neurokinin-PLP Derivative; SP-PLP; Tachykinin-Pyridoxal Phosphate Conjugate; [Arg1, Lys3(PLP)]-Substance P
EINECS	Contact for details

Quality Control

Our Substance P, α-n-Arg(1)-ε-n-Lys(3)-Di-(Pyridoxal Phosphate) is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and nuclear magnetic resonance (NMR) for structural verification. We adhere to high-purity research-grade standards, ensuring batch-to-batch consistency and reliability. A detailed Certificate of Analysis (COA) containing all specification data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.