Description

4-Cyano-3-(trifluoromethyl)benzaldehyde is a versatile and high-value aromatic aldehyde building block characterized by its cyano and trifluoromethyl substituents. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique electronic properties enable the creation of molecules with enhanced biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocycles and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the trifluoromethyl group improves lipophilicity and bioavailability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the research and production of organic electronic materials, such as OLEDs and semiconductors, due to its electron-withdrawing groups.
• Custom Synthesis and R&D: A critical reagent for contract research organizations (CROs) and academic laboratories exploring new chemical entities and reaction pathways.
• Fluorine Chemistry: An important substrate for further functionalization in fluorine chemistry, enabling the introduction of additional fluorinated motifs.

Basic Information

Product Name	4-Cyano-3-(trifluoromethyl)benzaldehyde
CAS No.	101066-58-4
Molecular Formula	C9H4F3NO
Molecular Weight	199.13 g/mol
Synonyms	3-(Trifluoromethyl)-4-cyanobenzaldehyde; 4-Formyl-2-(trifluoromethyl)benzonitrile; 2-(Trifluoromethyl)-4-cyanobenzaldehyde; 4-Cyano-3-trifluoromethylbenzaldehyde; 4-Cyano-α,α,α-trifluoro-m-tolualdehyde; Benzaldehyde, 4-cyano-3-(trifluoromethyl)-; 4-Cyano-3-(trifluoromethyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our 4-Cyano-3-(trifluoromethyl)benzaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical-grade intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider packaging under an inert gas such as nitrogen or argon. Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.