Description

Parathyroid Hormone (8-34) is a bioactive synthetic peptide fragment corresponding to amino acids 8-34 of the native parathyroid hormone. This compound is a critical research tool for studying calcium and phosphate metabolism, bone biology, and the structure-activity relationships of PTH. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers focused on endocrine disorders and metabolic bone diseases.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of PTH receptor binding, signaling pathways, and calcium homeostasis.
• Drug Discovery & Development: Serves as a key intermediate or pharmacophore model for designing novel therapeutics targeting osteoporosis, hyperparathyroidism, and hypoparathyroidism.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) for PTH-related analytes.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate the effects of PTH on osteoblast and osteoclast activity.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the bioactive regions of the full-length parathyroid hormone.

Basic Information

Product Name	Parathyroid Hormone (8-34)
CAS No.	101026-47-5
Molecular Formula	C128H210N40O39
Molecular Weight	~2980.3 g/mol
Synonyms	PTH (8-34); Parathyroid Hormone Fragment 8-34; hPTH (8-34); Human Parathyroid Hormone (8-34); PTHrP (8-34) (related fragment); [Ala8, Ala34]PTH(8-34) (common analog); Parathyrin (8-34); PTH-related protein fragment
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (8-34) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, peptide content, and solvent residues.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.