Description

2-Trifluoromethyl-Pyrimidin-5-Ol is a high-value fluorinated pyrimidine derivative, a key heterocyclic building block prized for its unique electronic and steric properties imparted by the trifluoromethyl group. Its primary value lies in enabling the synthesis of novel compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This intermediate is critically important for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop advanced active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in developing next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental profile.
• Material Science Precursor: Serves as a specialty monomer or additive in the research of advanced polymers and electronic materials.
• Chemical Synthesis: Employed in organic synthesis as a versatile scaffold for creating complex fluorinated heterocycles for various R&D applications.
• Ligand & Catalyst Development: Utilized in the design of novel ligands and organocatalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	2-Trifluoromethyl-Pyrimidin-5-Ol
CAS No.	100991-09-1
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	5-Hydroxy-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)pyrimidin-5-ol; 5-Pyrimidinol, 2-(trifluoromethyl)-; 2-Trifluoromethyl-5-hydroxypyrimidine; 5-Hydroxy-2-trifluoromethylpyrimidine; α,α,α-Trifluoro-5-hydroxy-2-pyrimidinemethanol (obsolete); TFMP-OH (abbreviation)
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-Pyrimidin-5-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.