Description

(D-Trp2,7,9)-Substance P CAS NO 100930-11-8 is a synthetic, biologically active peptide analog of the neuropeptide Substance P, specifically modified with D-tryptophan residues at positions 2, 7, and 9. This targeted modification enhances its metabolic stability and receptor selectivity, making it a critical tool for advanced research in neuropharmacology and signal transduction. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies for investigating tachykinin receptor function, pain pathways, and inflammatory processes.

Application

• Neuroscience Research: As a potent and selective tachykinin NK1 receptor antagonist for studying pain transmission, neurogenic inflammation, and central nervous system disorders.
• Pharmacological Studies: Used in receptor binding assays, functional bioassays, and signal transduction research to elucidate the role of Substance P in various physiological and pathological states.
• Drug Discovery & Development: Serves as a reference standard and a key intermediate in the development of novel therapeutics targeting neurokinin receptors for conditions like migraine, depression, and emesis.
• Biochemical Research: Employed in enzymatic stability studies and as a model peptide for investigating the effects of D-amino acid substitution on peptide structure, activity, and degradation.
• Academic Research: A fundamental reagent for university and institutional labs focusing on peptide chemistry, neurobiology, and molecular pharmacology.

Basic Information

Product Name	(D-Trp2,7,9)-Substance P
CAS No.	100930-11-8
Molecular Formula	C78H108N20O14S
Molecular Weight	1581.9 g/mol
Synonyms	(D-Trp2, D-Trp7, D-Trp9)-Substance P; [D-Trp2,7,9]-Substance P; Arg-Pro-Lys-Pro-D-Trp-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2; SP (D-Trp2,7,9); Tachykinin NK1 Receptor Antagonist (D-Trp2,7,9); Substance P (D-Trp2,7,9) analog; Neurokinin-1 Receptor Antagonist Peptide
EINECS	Contact for details

Quality Control

Every batch of (D-Trp2,7,9)-Substance P is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of identity, purity, and potency. Our quality commitment includes comprehensive characterization by HPLC, MS, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified purity criteria, typically ≥95% (HPLC). We support research and GMP-grade requirements with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.