Description

His-Ser 4-Methoxy-β-Naphthylamide Acetate Salt is a specialized synthetic peptide derivative designed for advanced biochemical research and development. This compound is valued for its role as a chromogenic or fluorogenic enzyme substrate, particularly for detecting specific protease activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in enzymology, assay development, and high-throughput screening. The product is supplied as a high-purity reference standard to ensure reliable and reproducible experimental results.

Application

• Protease Activity Assays: Serves as a sensitive chromogenic or fluorogenic substrate for the detection and quantification of specific proteolytic enzymes, such as trypsin, chymotrypsin, or other serine proteases.
• Biochemical Research: Used in fundamental enzymology studies to investigate enzyme kinetics, inhibition mechanisms, and substrate specificity.
• Diagnostic Reagent Development: A key component in the formulation of diagnostic kits for detecting enzyme-related pathologies or biological processes.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize potential therapeutic enzyme inhibitors.
• Cell Biology Studies: Applied in assays to monitor protease activity within cellular systems or tissue samples.
• Quality Control in Biomanufacturing: Used as a standard to validate the activity and specificity of enzyme preparations used in industrial processes.

Basic Information

Product Name	His-Ser 4-Methoxy-β-Naphthylamide Acetate Salt
CAS No.	100929-87-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	H-His-Ser-4-Methoxy-2-Naphthylamide Acetate; L-Histidyl-L-seryl-4-methoxy-2-naphthylamide acetate; 4-Methoxy-β-naphthylamide derivative of His-Ser; Protease substrate His-Ser-4MβNA; H-His-Ser-4MeO-βNA Acetate; Chromogenic substrate for serine proteases; Fluorogenic peptide substrate; His-Ser-4-Methoxy-β-NA Acetate Salt
EINECS	Contact for details

Quality Control

Our His-Ser 4-Methoxy-β-Naphthylamide Acetate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets exacting standards for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term stability, consider storage at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.