Description

Tyr-D-Ala-Gly-Phe-D-Met-Nh2 Acetate Salt is a synthetic, biologically active peptide derivative, specifically a modified enkephalin analog with a D-amino acid configuration. This molecular design enhances its metabolic stability and receptor selectivity, making it a critical tool for advanced biochemical and pharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, pain management, and peptide-based drug discovery. The compound is supplied as a high-purity, lyophilized powder to ensure optimal performance in sensitive experimental systems.

Application

• Neuroscience Research: As a potent and selective ligand for studying opioid receptor (MOR, DOR) subtypes, their signaling pathways, and downstream effects.
• Analgesic Drug Development: Serving as a key reference standard or lead compound in the discovery of novel, non-addictive pain therapeutics.
• Biochemical Assays: Used in competitive binding assays, receptor autoradiography, and functional cell-based tests to evaluate compound activity.
• Metabolic Stability Studies: Investigating the impact of D-amino acid substitution on peptide degradation profiles and in vivo half-life.
• Academic & Institutional Research: Fundamental research into the endogenous opioid system, peptide structure-activity relationships (SAR), and neuropharmacology.
• Quality Control & Reference Standard: Acting as a certified reference material (CRM) for the analysis and validation of related peptide pharmaceuticals.

Basic Information

Product Name	Tyr-D-Ala-Gly-Phe-D-Met-Nh2 Acetate Salt
CAS No.	100929-63-3
Molecular Formula	C31H43N7O8S • xC2H4O2
Molecular Weight	681.80 g/mol (Free base, anhydrous)
Synonyms	[D-Ala2, D-Met5]-Enkephalin Acetate; DADME Acetate; Tyr-D-Ala-Gly-Phe-D-Met-NH2 acetate; H-Tyr-D-Ala-Gly-Phe-D-Met-NH2 acetate salt; Opioid peptide analog; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenyl-N-[[(2R)-1-(methylsulfanyl)-1-oxopropan-2-yl]methyl]propanamide acetate
EINECS	Contact for details

Quality Control

Our Tyr-D-Ala-Gly-Phe-D-Met-Nh2 Acetate Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, solvent content, and specific tests is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep under inert atmosphere. Allow the vial to equilibrate to room temperature in a dry atmosphere before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/Titration)	1.0 - 2.0 eq
Peptide Content (Amino Acid Analysis)	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.