Description

Des-Tyr1-Methionine Enkephalinamide Acetate Salt is a synthetic peptide analog of the endogenous opioid peptide enkephalin, modified for enhanced metabolic stability and receptor selectivity. This compound is a critical research tool for investigating opioid receptor pharmacology, signal transduction pathways, and the physiological roles of the enkephalinergic system. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biochemical researchers focused on neuropharmacology and pain management.

Application

• Neuroscience Research: A key ligand for studying delta (δ) and mu (μ) opioid receptor binding, activation, and downstream effects in vitro and in vivo.
• Pharmacological Assay Development: Used as a reference standard in high-throughput screening (HTS) campaigns to discover novel analgesics with reduced side-effect profiles.
• Signal Transduction Studies: Employed to elucidate G-protein coupled receptor (GPCR) mechanisms, including adenylate cyclase inhibition and potassium channel modulation.
• Biochemical Tool Compound: Serves as a metabolically stable agonist in experiments requiring prolonged receptor stimulation without rapid enzymatic degradation.
• Pain Research Models: Applied in animal models to study the antinociceptive effects and tolerance development associated with opioid receptor agonists.
• Peptide Chemistry Reference: Acts as a building block or analytical standard for the synthesis and quality control of related neuroactive peptides.

Basic Information

Product Name	Des-Tyr1-Methionine Enkephalinamide Acetate Salt
CAS No.	100929-59-7
Molecular Formula	C26H41N7O7S • xC2H4O2
Molecular Weight	595.71 g/mol (free base)
Synonyms	Met-Enkephalinamide, Des-Tyr1; H-Met-Enkephalinamide; [Met5]-Enkephalinamide; Methionine Enkephalin Amide; Opioid Peptide Analog; Tyr-Gly-Gly-Phe-Met-NH2 (modified); FK 33-824 derivative; RG 100-000
EINECS	Contact for details

Quality Control

Our Des-Tyr1-Methionine Enkephalinamide Acetate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specification parameters to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 8.0%
Acetate Content (IC)	5.0 - 12.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.