Description

D-Ala2 D-Met5-Enkephalin Acetate is a synthetic, biologically active peptide analog of the endogenous opioid peptide enkephalin, designed for enhanced metabolic stability and receptor selectivity. This compound is a critical research tool for studying opioid receptor pharmacology, pain pathways, and neurobiology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience and analgesic drug discovery.

Application

• Neuroscience Research: A standard ligand for investigating the function and binding characteristics of delta (δ) and mu (μ) opioid receptors in vitro and in vivo.
• Pharmacological Studies: Used to study pain modulation, tolerance, dependence, and the physiological roles of the endogenous opioid system.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design of novel, non-addictive analgesic agents.
• Biochemical Assays: Employed in receptor binding assays, functional cell-based assays (e.g., cAMP inhibition), and signal transduction studies.
• Academic & Clinical Research: Supports fundamental research into neurological disorders, addiction mechanisms, and stress responses.

Basic Information

Product Name	D-Ala2 D-Met5-Enkephalin Acetate
CAS No.	100929-58-6
Molecular Formula	C29H39N5O7S • xC2H4O2
Molecular Weight	625.72 g/mol (free base)
Synonyms	DADME; [D-Ala2, D-Met5]-Enkephalin acetate salt; Tyr-D-Ala-Gly-Phe-D-Met-NH2 acetate; D-Alanine2, D-Methionine5-enkephalin acetate; DAMEA; Opioid peptide analog; Delta opioid receptor agonist
EINECS	Contact for details

Quality Control

Our D-Ala2 D-Met5-Enkephalin Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and residual solvents are provided to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	3.0 - 8.0 mol/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.