Description

Tyr-D-Ala-Gly-Phe-Leu-Nh2 Acetate Salt is a synthetic pentapeptide analog of the endogenous opioid peptide [Leu]enkephalin, modified with a D-alanine residue to enhance its metabolic stability. This compound is a critical research tool for studying opioid receptor pharmacology, signal transduction, and pain modulation pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, analgesic development, and peptide-based therapeutics.

Application

• Neuroscience Research: Used as a selective ligand for studying delta (δ) and mu (μ) opioid receptor binding, activation, and downstream effects in vitro and in vivo.
• Analgesic Drug Discovery: Serves as a reference standard and lead compound in the development of novel, non-addictive pain management therapies.
• Biochemical Assays: Employed in competitive binding assays, receptor autoradiography, and functional studies (e.g., cAMP inhibition, GTPγS binding) to characterize opioid system activity.
• Peptide Chemistry & Stability Studies: Acts as a model compound for investigating the impact of D-amino acid substitution on peptide conformation, protease resistance, and bioavailability.
• Cell Signaling Pathway Analysis: Utilized to probe the role of opioid receptors in cellular processes such as ion channel modulation and neurotransmitter release.

Basic Information

Product Name	Tyr-D-Ala-Gly-Phe-Leu-Nh2 Acetate Salt
CAS No.	100929-55-3
Molecular Formula	C34H48N6O8 • xC2H4O2
Molecular Weight	668.79 g/mol (free base)
Synonyms	DADLE; [D-Ala2, D-Leu5]-Enkephalin Acetate; Tyr-D-Ala-Gly-Phe-D-Leu-NH2 Acetate; D-Ala2,Leu5-Enkephalin Acetate; H-Tyr-D-Ala-Gly-Phe-D-Leu-NH2 Acetate; δ-Selective Opioid Peptide; (2S)-2-[[(2S)-2-[[2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoic acid; 5-L-Leucine-2-D-alanine-enkephalin acetate salt
EINECS	Contact for details

Quality Control

Our Tyr-D-Ala-Gly-Phe-Leu-Nh2 Acetate Salt is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	1.0 - 2.0 equivalents
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.