Description

(D-Ala2,D-Met5)-Enkephalin CAS NO 100929-50-8 is a synthetic, biologically active pentapeptide analog of the endogenous opioid peptide enkephalin, featuring D-amino acid substitutions at positions 2 and 5. This modification enhances its metabolic stability and receptor selectivity, making it a critical tool for neuropharmacological research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the study of opioid receptor function, pain pathways, and the development of novel analgesic compounds.

Application

• Neuroscience Research: Used as a selective ligand for studying δ-opioid receptor (DOR) binding, activation, and signaling mechanisms in vitro and in vivo.
• Pharmacological Assays: Serves as a reference standard in competitive binding assays and functional tests to evaluate the potency of new opioid compounds.
• Pain Research: Employed in experimental models to investigate the role of enkephalinergic systems in analgesia and to explore potential therapeutic targets for chronic pain.
• Biochemical Studies: Utilized in structure-activity relationship (SAR) studies to understand the impact of D-amino acid incorporation on peptide stability and biological activity.
• Drug Discovery: Acts as a key intermediate or reference molecule in the research and development pipeline for next-generation, non-addictive pain medications.

Basic Information

Product Name	(D-Ala2,D-Met5)-Enkephalin
CAS No.	100929-50-8
Molecular Formula	C28H37N5O7S
Molecular Weight	587.69 g/mol
Synonyms	DADME; [D-Ala2, D-Met5]-Enkephalin; Tyr-D-Ala-Gly-Phe-D-Met; H-Tyr-D-Ala-Gly-Phe-D-Met-OH; (D-Alanine2, D-Methionine5)-Enkephalin; Opioid peptide analog; δ-opioid receptor agonist
EINECS	Contact for details

Quality Control

Our (D-Ala2,D-Met5)-Enkephalin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specified parameters to ensure compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.