Description

Tyr-Corticotropin Releasing Factor Human, Rat is a synthetic peptide analog of the endogenous corticotropin-releasing hormone (CRH), a critical neuropeptide in the hypothalamic-pituitary-adrenal (HPA) axis. This compound is essential for advanced research in neuroendocrinology, stress physiology, and the development of therapeutic agents targeting stress-related disorders. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on neuroscience and endocrinology.

Application

• Neuroscientific Research: Used as a potent agonist to study the activation and regulation of the HPA axis, CRH receptor signaling, and stress response mechanisms in vivo and in vitro.
• Pharmacological Studies: Serves as a reference standard and tool compound for screening and developing novel CRH receptor antagonists for anxiety, depression, and addiction.
• Endocrine System Modeling: Applied in cell-based assays and animal models to investigate disorders like Cushing's syndrome and adrenal insufficiency.
• Biomarker Development: Utilized in the development and validation of immunoassays (e.g., ELISA, RIA) for detecting CRH-related peptides.
• Drug Delivery & Formulation Research: Acts as a model peptide for studying blood-brain barrier penetration and stability of peptide-based therapeutics.

Basic Information

Product Name	Tyr-Corticotropin Releasing Factor Human, Rat
CAS No.	100915-92-2
Molecular Formula	C209H344N60O63S
Molecular Weight	4879.4 g/mol
Synonyms	Tyr-CRF; Tyr-Corticotropin Releasing Hormone; Tyr-CRH; h/rCRF (Tyr0); Tyr0-Corticotropin Releasing Factor; Tyr0-CRF (human, rat); Tyr0-Sauvagine; O-Tyrosyl-Corticotropin Releasing Factor; CRF, Tyr0-
EINECS	Contact for details

Quality Control

Our Tyr-Corticotropin Releasing Factor Human, Rat is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to cGMP guidelines for the production of research-grade peptides, ensuring traceability and reliability for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.