Description

Na-Cbz-Arg-Arg 4-Methoxy-B-Naphthylamide is a specialized synthetic peptide derivative designed for biochemical research and development. This compound is a key chromogenic substrate used in the study and detection of specific protease enzyme activity. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors for enzyme kinetics, inhibitor screening, and assay development.

Application

• Protease Enzyme Assays: Acts as a sensitive chromogenic substrate for the detection and quantification of trypsin-like serine proteases, including thrombin and plasmin.
• Biochemical Research: Used in kinetic studies to determine enzyme activity, inhibition constants (Ki), and catalytic mechanisms in academic and industrial R&D laboratories.
• Diagnostic Reagent Development: Serves as a critical component in the formulation of diagnostic kits for coagulation disorders and other medical conditions linked to protease activity.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors as potential drug candidates.
• Quality Control in Biomanufacturing: Used to monitor and validate the activity of enzyme preparations used in bioprocessing and therapeutic protein production.

Basic Information

Product Name	Na-Cbz-Arg-Arg 4-Methoxy-B-Naphthylamide
CAS No.	100900-19-4
Molecular Formula	C33H46N10O7
Molecular Weight	694.79 g/mol
Synonyms	Benzyloxycarbonyl-Arg-Arg-4-Methoxy-2-Naphthylamide; Z-Arg-Arg-4-Methoxy-β-Naphthylamide; Cbz-Arg-Arg-4MβNA; Z-Arg-Arg-MNA; Chromogenic Substrate for Trypsin-like Proteases; Nα-Carbobenzoxy-L-arginyl-L-arginine 4-methoxy-2-naphthylamide; 4-Methoxy-2-naphthylamine, N-(N2-(N2-(benzyloxycarbonyl)-L-arginyl)-L-arginyl)-
EINECS	Contact for details

Quality Control

Our Na-Cbz-Arg-Arg 4-Methoxy-B-Naphthylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and verification of performance in standard enzymatic assays. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility Test	Soluble in DMSO, DMF; slightly soluble in water
Functional Activity	Conforms to reference standard in enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.