Description

2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Phenyl-Propionic Acid is a key Fmoc-protected amino acid derivative, essential for solid-phase peptide synthesis (SPPS). This compound provides critical protection for the amine group during the sequential assembly of peptides, ensuring high coupling efficiency and purity. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the production of therapeutic peptides, peptide hormones, and research biochemicals.

Application

• As a crucial building block in solid-phase peptide synthesis (SPPS) for the production of custom peptides.
• For the research and development of therapeutic peptides and peptide-based drug candidates.
• In the synthesis of peptide libraries for high-throughput screening in drug discovery.
• As a specialized reagent for the chemical synthesis of proteins and complex biomolecules.
• For the preparation of conjugates in bioconjugation and linker chemistry.
• In academic and industrial research focused on peptide structure-activity relationships (SAR).

Basic Information

Product Name	2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Phenyl-Propionic Acid
CAS No.	100750-05-8
Molecular Formula	C24H21NO4
Molecular Weight	387.43 g/mol
Synonyms	Fmoc-Phenylalanine-OH; Fmoc-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine; N-α-Fmoc-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-phenylpropanoic acid; Fmoc-L-Phe; N-Fmoc-L-phenylalanine; L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Phenyl-Propionic Acid is manufactured under strict quality systems suitable for research and pharmaceutical applications. We provide material with typical purity levels exceeding 98% (HPLC), ensuring optimal performance in sensitive peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.