Description

4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidin-6-Amine is a high-purity heterocyclic building block of significant importance in pharmaceutical research and development. This compound serves as a critical synthetic intermediate for the creation of novel therapeutic agents, particularly kinase inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of targeted small-molecule drugs for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent and selective kinase inhibitors, such as Janus kinase (JAK) and Bruton's tyrosine kinase (BTK) inhibitors.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Biochemical Tool Compound: Serves as a core scaffold for developing probe molecules to study specific enzymatic pathways and biological targets.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis and scale-up projects.
• Academic Research: Utilized in university laboratories for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidin-6-Amine
CAS No.	100644-65-3
Molecular Formula	C5H4ClN5
Molecular Weight	169.57 g/mol
Synonyms	4-Chloro-6-amino-1H-pyrazolo[3,4-d]pyrimidine; 4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine; 6-Amino-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; 4-Chloro-6-aminopyrazolopyrimidine; 4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine; 4-Chloro-6-aminopyrazolo[3,4-d]pyrimidine; 4-Chloro-6-amino-1H-pyrazolo[3,4-d]pyrimidine; 4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine (CAS 100644-65-3)
EINECS	Contact for details

Quality Control

Our 4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidin-6-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.