Description

tert-Butoxycarbonylleucyl-Leucyl-Leucyl-Leucyl-Aminoisobutyryl-Leucyl-Leucyl-Leucyl-Leucine Benzyl Ester is a complex, sequence-specific peptide derivative designed for advanced research and development. This compound is a critical building block in the synthesis of specialized peptides and peptidomimetics, offering precise control over molecular structure and bioactivity. It is primarily utilized by pharmaceutical researchers, biochemists, and process development scientists working in drug discovery, proteomics, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Drug Discovery: Serves as a key intermediate in the solid-phase or solution-phase synthesis of complex peptide-based drug candidates targeting various diseases.
• Protease Substrate Development: Used in the design and synthesis of specific substrates to study the activity and inhibition of proteolytic enzymes like proteasomes or cathepsins, due to its leucine-rich sequence.
• Biochemical Tool Compound: Employed in academic and industrial laboratories to investigate protein-protein interactions, cell signaling pathways, and mechanisms of intracellular degradation.
• Peptidomimetic Synthesis: Acts as a precursor for creating modified peptides with enhanced stability, bioavailability, or receptor selectivity by incorporating the tert-butoxycarbonyl (Boc) and benzyl ester protecting groups.
• Process Development & Scale-up: Used in optimizing synthetic routes for the GMP-compliant manufacturing of peptide active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	tert-Butoxycarbonylleucyl-Leucyl-Leucyl-Leucyl-Aminoisobutyryl-Leucyl-Leucyl-Leucyl-Leucine Benzyl Ester
CAS No.	100642-98-6
Molecular Formula	C73H124N10O13
Molecular Weight	1357.83 g/mol
Synonyms	Boc-Leu-Leu-Leu-Leu-Aib-Leu-Leu-Leu-Leu-OBzl; Boc-L-Leu-L-Leu-L-Leu-L-Leu-Aib-L-Leu-L-Leu-L-Leu-L-Leu-OBzl; (Boc)Leu-Leu-Leu-Leu-Aib-Leu-Leu-Leu-Leu-OBzl; Leu-Leu-Leu-Leu-Aib-Leu-Leu-Leu-Leu Benzyl Ester Boc Derivative; N-(tert-Butoxycarbonyl)leucylleucylleucylleucyl-2-aminoisobutyrylleucylleucylleucylleucine Benzyl Ester; Peptide Synthesis Intermediate CAS 100642-98-6; Proteasome Inhibitor Precursor
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of tert-Butoxycarbonylleucyl-Leucyl-Leucyl-Leucyl-Aminoisobutyryl-Leucyl-Leucyl-Leucyl-Leucine Benzyl Ester is characterized using advanced analytical techniques, including HPLC, MS, and NMR, to confirm identity, purity, and sequence integrity. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.