Description

Dolichol Monophosphate Glucosamine is a key phosphorylated glycolipid intermediate essential for the biosynthesis of N-linked glycoproteins. This compound plays a critical role in the dolichol pathway, serving as a membrane-anchored carrier for oligosaccharide assembly before transfer to nascent proteins. It is primarily utilized by researchers and manufacturers in the fields of biochemistry, glycobiology, and pharmaceutical development, particularly for studying glycosylation disorders and developing therapeutic interventions.

Application

• Biochemical Research: A vital substrate for in vitro studies of the N-linked glycosylation pathway and enzyme kinetics.
• Glycobiology Studies: Used to investigate congenital disorders of glycosylation (CDGs) and related metabolic pathways.
• Pharmaceutical Development: Serves as a reference standard and intermediate in the development of glycosylation-targeting therapies.
• Enzyme Assay Substrate: Employed as a specific substrate for assays involving glycosyltransferases like ALG enzymes.
• Cell Culture & Metabolic Labeling: Used in metabolic engineering and labeling experiments to trace glycan biosynthesis in cultured cells.
• Academic & Industrial R&D: Fundamental tool for universities and biotech companies exploring protein post-translational modifications.

Basic Information

Product Name	Dolichol Monophosphate Glucosamine
CAS No.	100631-16-1
Molecular Formula	C_(n)H_(2n+1)O_(10)P (Variable 'n' based on dolichol chain length, typically C80-C105)
Molecular Weight	Variable (Dependent on dolichol chain length). Contact for details.
Synonyms	Dolichyl Phosphate N-Acetylglucosamine; Dolichol-P-GlcNAc; Dolichyl Phosphate GlcNAc; Undecaprenyl Phosphate Glucosamine (bacterial analog); GlcNAc-1-P-Dolichol; Dolichol Diphosphate N-Acetylglucosamine; Lipid-linked GlcNAc; N-Acetylglucosaminyldiphosphodolichol
EINECS	Contact for details

Quality Control

Our Dolichol Monophosphate Glucosamine is produced under stringent conditions to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, MS, and NMR for structural confirmation and purity assessment. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area Percent)
Solubility	Soluble in chloroform/methanol/water mixtures
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.