Description

[[(2,3,4-Trifluorophenyl)Amino]Methylene]Propanedioic Acid Diethyl Ester is a high-value fluorinated organic intermediate characterized by its unique diethyl malonate derivative structure. This compound is essential for the synthesis of complex molecules, particularly in advanced pharmaceutical research and agrochemical development. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life sciences industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the trifluorophenyl moiety imparts specific biological activity.
• Material Science Research: Serves as a precursor for the development of specialty polymers and advanced organic materials with tailored electronic or surface properties.
• Ligand and Catalyst Development: Employed in the creation of novel chelating ligands and organocatalysts for asymmetric synthesis and transition metal catalysis.
• Fluorine Chemistry Studies: A valuable reagent for academic and industrial research focused on understanding and exploiting the unique effects of fluorine substitution in organic molecules.

Basic Information

Product Name	[[(2,3,4-Trifluorophenyl)Amino]Methylene]Propanedioic Acid Diethyl Ester
CAS No.	100501-60-8
Molecular Formula	C14H15F3NO4
Molecular Weight	318.27 g/mol
Synonyms	Diethyl 2-[[(2,3,4-Trifluorophenyl)amino]methylene]malonate; Diethyl (2,3,4-Trifluoroanilino)methylene malonate; Propanedioic acid, [[(2,3,4-trifluorophenyl)amino]methylene]-, diethyl ester; (2,3,4-Trifluorophenylamino)methylene malonic acid diethyl ester; (E)-Diethyl 2-((2,3,4-trifluorophenylimino)methyl)malonate; Malonic acid, [(2,3,4-trifluoroanilino)methylene]-, diethyl ester
EINECS	Contact for details

Quality Control

Our production of [[(2,3,4-Trifluorophenyl)Amino]Methylene]Propanedioic Acid Diethyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is fully characterized and undergoes rigorous analytical testing, including HPLC for assay and purity determination. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.