Description

Boc-3-(1-Pyrenyl)-L-Alanine is a specialized, non-natural amino acid derivative where the L-alanine side chain is functionalized with a pyrenyl group and protected at the amine terminus with a tert-butyloxycarbonyl (Boc) group. This compound matters as a critical building block for the synthesis of novel peptides and bioconjugates, enabling the introduction of a large, fluorescent aromatic system for probing protein structure, interactions, and dynamics. It is primarily needed by researchers and manufacturers in pharmaceutical R&D, chemical biology, and materials science for developing fluorescent probes, peptide-based therapeutics, and advanced polymeric materials.

Application

• Fluorescent Peptide Synthesis: Incorporation into peptide sequences to create intrinsic fluorescent labels for studying protein folding, aggregation, and biomolecular interactions.
• Chemical Biology Probes: Serving as a key precursor for developing activity-based probes and biosensors that utilize pyrene's excimer formation properties.
• Peptidomimetic Drug Discovery: Used in medicinal chemistry to synthesize and screen novel peptidomimetics with enhanced aromatic stacking interactions for target binding.
• Polymer and Material Science: Acting as a functional monomer for creating smart polymers, supramolecular assemblies, and organic electronic materials with unique photophysical properties.
• Bioconjugation and Labeling: Facilitating the site-specific labeling of proteins, antibodies, and other biomolecules after Boc deprotection and subsequent coupling reactions.
• Academic and Industrial Research: A valuable tool for basic research in organic synthesis, photochemistry, and the development of advanced diagnostic platforms.

Basic Information

Product Name	Boc-3-(1-Pyrenyl)-L-Alanine
CAS No.	100442-89-5
Molecular Formula	C24H23NO4
Molecular Weight	389.45 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3-(1-pyrenyl)-L-alanine; Boc-Pya-OH; (S)-2-((tert-Butoxycarbonyl)amino)-3-(pyren-1-yl)propanoic acid; N-Boc-3-(1-pyrenyl)-L-alanine; tert-Butyl (S)-(1-carboxy-2-(pyren-1-yl)ethyl)carbamate; 1-Pyrenealanine, N-[(1,1-dimethylethoxy)carbonyl]-; Boc-L-3-(1-Pyrenyl)alanine
EINECS	Contact for details

Quality Control

Our Boc-3-(1-Pyrenyl)-L-Alanine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with research and development standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.