Description

3'-Deoxy-3'-Fluorokanamycin A is a chemically modified derivative of the aminoglycoside antibiotic kanamycin A, where a fluorine atom is introduced at the 3'-position. This structural modification is of significant interest in pharmaceutical research for developing novel antibacterial agents and studying structure-activity relationships. It serves as a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on antibiotic development and resistance studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel fluorinated aminoglycoside antibiotics.
• Biochemical Research: Used as a reference standard in studies investigating the mechanism of action and resistance of aminoglycoside antibiotics.
• Antibacterial Agent Development: Serves as a lead compound for the research and development of new antibacterial therapeutics with potentially improved efficacy or reduced toxicity.
• Microbiology Studies: Employed in laboratory research to understand bacterial ribosome interaction and inhibition by modified aminoglycosides.
• Analytical Standard: Used for method development, calibration, and quality control in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	3'-Deoxy-3'-Fluorokanamycin A
CAS No.	100343-09-7
Molecular Formula	C18H36FN5O10
Molecular Weight	501.50 g/mol
Synonyms	3'-Deoxy-3'-fluorokanamycin A; 3'-Fluoro-3'-deoxykanamycin A; 3-FDK; 3'-Fluorokanamycin A; Kanamycin A, 3'-deoxy-3'-fluoro-; 1-N-[(2S,3S,4S,5R)-5-Amino-2-fluoromethyl-3,4-dihydroxytetrahydrofuran-2-yl]-4,6-diamino-4,6-dideoxy-α-D-glucopyranosyl-(1→4)-O-2-deoxy-6-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino-α-D-glucopyranoside
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-3'-Fluorokanamycin A is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.