Description

n-Formyl-Nle-Leu-Phe-Tyr is a synthetic, formylated tetrapeptide derivative featuring the amino acids norleucine, leucine, phenylalanine, and tyrosine. This compound is a valuable biochemical tool and research intermediate, particularly in the study of chemotaxis and receptor-ligand interactions. It is primarily utilized by researchers and developers in the fields of immunology, pharmacology, and cell biology for experimental and diagnostic applications.

Application

• Biochemical Research: Used as a synthetic chemoattractant peptide in studies of neutrophil and monocyte chemotaxis and activation.
• Receptor Binding Assays: Serves as a ligand for formyl peptide receptors (FPRs) in competitive binding and signal transduction studies.
• Inflammation Research: Employed in vitro and ex vivo models to investigate inflammatory pathways and immune cell responses.
• Pharmaceutical Development: Acts as a reference standard or intermediate in the development of anti-inflammatory or immunomodulatory agents.
• Diagnostic Reagent Manufacturing: Used in the formulation of kits and reagents for research and clinical diagnostics related to immune function.
• Cell Signaling Studies: Applied to elucidate mechanisms of G-protein coupled receptor (GPCR) activation and downstream cellular events.

Basic Information

Product Name	n-Formyl-Nle-Leu-Phe-Tyr
CAS No.	100007-40-7
Molecular Formula	C36H50N5O8
Molecular Weight	680.81 g/mol
Synonyms	Formyl-Norleu-Leu-Phe-Tyr-OH; fNle-Leu-Phe-Tyr; N-Formyl-L-norleucyl-L-leucyl-L-phenylalanyl-L-tyrosine; For-Nle-Leu-Phe-Tyr; Chemotactic Peptide fNleLFNY; Formyl-Met-Leu-Phe-Tyr Analog; Formylated Tetrapeptide; CHO-Nle-Leu-Phe-Tyr
EINECS	Contact for details

Quality Control

Our n-Formyl-Nle-Leu-Phe-Tyr is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee reproducible performance in your research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.