Description

n-α-Carbobenzoxy-D-Histidine Hydrazide is a protected derivative of the amino acid D-Histidine, specifically designed for peptide synthesis. This compound is a critical chiral building block, enabling the controlled incorporation of the D-histidine residue into peptide chains while preventing unwanted side reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel bioactive peptides, peptidomimetics, and potential therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key chiral intermediate for the controlled introduction of D-histidine in custom peptide sequences.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, hormone analogs, and enzyme inhibitors.
• Bioconjugation & Labeling: The reactive hydrazide group can be utilized for site-specific conjugation with aldehydes or ketones in bioconjugation strategies.
• Chemical Biology Probes: Synthesis of labeled or modified histidine-containing peptides for studying protein-protein interactions and enzyme mechanisms.
• Process Development: Scaling up synthesis routes for peptides containing D-histidine for preclinical and clinical studies.
• Academic Research: Investigating the structure-activity relationships (SAR) of peptides and exploring novel peptide architectures.

Basic Information

Product Name	n-α-Carbobenzoxy-D-Histidine Hydrazide
CAS No.	100002-58-2
Molecular Formula	C14H18N6O4
Molecular Weight	334.33 g/mol
Synonyms	Z-D-His-NHNH2; Cbz-D-His-NHNH2; Nα-Carbobenzoxy-D-histidine hydrazide; D-Histidine, N-[(phenylmethoxy)carbonyl]-, hydrazide; (R)-2-((((Benzyloxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanehydrazide; CBZ-D-Histidine Hydrazide; Z-D-Histidine Hydrazide; N-CBZ-D-Histidine Hydrazide
EINECS	Contact for details

Quality Control

Our n-α-Carbobenzoxy-D-Histidine Hydrazide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation and moisture. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.