Description

cis-Cyclo(Pro-Pro) CAS NO 19943-27-2 is a synthetic cyclic dipeptide, also known as a diketopiperazine (DKP), formed from two proline residues. This compound is a valuable chiral building block and scaffold in medicinal chemistry and pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies for drug discovery, peptide mimetics development, and as a reference standard in analytical chemistry.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold for designing novel drug candidates, particularly in oncology and neurology.
• Peptidomimetics Research: Used to create stable, bioactive analogs of linear peptides with improved metabolic stability.
• Chemical Biology Probe: Acts as a tool compound to study enzyme inhibition and protein-protein interactions.
• Chiral Catalyst or Ligand: Explored in asymmetric synthesis due to its rigid, chiral structure.
• Reference Standard: Essential for quality control and method development in analytical laboratories using HPLC or LC-MS.
• Cosmetic Peptide Precursor: Investigated for potential use in advanced skincare formulations.

Basic Information

Product Name	cis-Cyclo(Pro-Pro)
CAS No.	19943-27-2
Molecular Formula	C10H14N2O2
Molecular Weight	194.23 g/mol
Synonyms	Cyclo(L-prolyl-L-prolyl); (3S,8aS)-3,6-Diazabicyclo[5.3.0]decane-2,5-dione; L-Prolyl-L-proline anhydride; cis-Cyclo(L-Pro-L-Pro); L-Pro-L-Pro Diketopiperazine; DKP-Pro-Pro; 2,5-Diketopiperazine-3,6-di(propanoic acid); 19943-27-2
EINECS	Contact for details

Quality Control

Our cis-Cyclo(Pro-Pro) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (cis isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.