Description

Z-Tyr-NH2 is a protected tyrosine derivative, specifically the C-terminal amide of Z-tyrosine, widely utilized as a key building block in peptide synthesis. Its primary value lies in providing a versatile, orthogonally protected tyrosine residue for the controlled construction of complex peptides and peptidomimetics. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental protected amino acid component for the automated synthesis of custom peptide sequences.
• Pharmaceutical R&D: Used in the research and development of novel peptide-based drugs, including hormone analogs and receptor-targeting therapeutics.
• Bioconjugation: Serves as a precursor for creating tyrosine-containing linkers used in antibody-drug conjugates (ADCs) and protein labeling.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: A standard reagent for studying enzyme kinetics, protein-protein interactions, and signal transduction pathways.
• Production of Specialty Peptides: Critical for manufacturing peptides requiring specific, unprotected functional groups for further modification.

Basic Information

Product Name	Z-Tyr-NH2
CAS No.	19898-39-6
Molecular Formula	C17H18N2O4
Molecular Weight	314.34 g/mol
Synonyms	N-Carbobenzoxy-L-tyrosinamide; Z-L-Tyrosine amide; Z-Tyrosine amide; N-(Benzyloxycarbonyl)-L-tyrosinamide; Nα-Cbz-L-tyrosinamide; (2S)-3-(4-Hydroxyphenyl)-2-[(phenylmethoxy)formamido]propanamide; CBZ-Tyr-NH2; Cbz-L-Tyr-NH2
EINECS	243-372-3

Quality Control

Our Z-Tyr-NH2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements, including those for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Melting Point	Contact for details
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.