Description

n-Ethoxycarbonyl-L-Phenylalanine is a protected derivative of the essential amino acid L-phenylalanine, where the carboxylic acid group is masked as an ethyl ester. This modification is crucial for its primary role as a key chiral building block and intermediate in the synthesis of complex pharmaceuticals and bioactive peptides. It is particularly valuable for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity, enantiomerically pure intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), including enzyme inhibitors and peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid derivative to prevent unwanted side reactions.
• Proteomics Research: Serves as a building block for creating custom peptides and molecular probes in biochemical and proteomics research.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in asymmetric catalytic reactions to construct complex molecules with high stereoselectivity.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring specific chiral centers.

Basic Information

Product Name	n-Ethoxycarbonyl-L-Phenylalanine
CAS No.	19887-32-2
Molecular Formula	C₁₂H₁₅NO₄
Molecular Weight	237.25 g/mol
Synonyms	L-Phenylalanine, N-ethoxycarbonyl-; N-Carbethoxy-L-phenylalanine; N-(Ethoxycarbonyl)-L-phenylalanine; Ethyl N-[(benzyloxy)carbonyl]-L-phenylalaninate (related protected form); Z-L-Phe-OEt (common abbreviation); N-Z-L-Phenylalanine ethyl ester; (S)-2-((Ethoxycarbonyl)amino)-3-phenylpropanoic acid; Fmoc-Phe-OEt (when using Fmoc protection strategy)
EINECS	Contact for details

Quality Control

Our n-Ethoxycarbonyl-L-Phenylalanine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and synthesis. Certificates of Analysis (COA) are provided with each shipment, detailing parameters such as chiral purity, chemical purity, and impurity profiles. We can support compliance with cGMP and ICH guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity ([α]D / HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.