Description

n-Acetyl-D-Leucine is a high-purity, non-natural enantiomer of the acetylated amino acid derivative. This compound serves as a critical chiral building block and intermediate in advanced pharmaceutical synthesis and biochemical research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics, peptide synthesis, and as a standard in analytical method development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), particularly in peptide-based drugs and metabolic modulators.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Peptide Synthesis: Serves as a protected D-leucine derivative in solid-phase and solution-phase peptide synthesis to introduce specific chiral centers.
• Analytical Standard: Employed as a high-purity reference standard in HPLC, LC-MS, and chiral chromatography for method validation and quality control.
• Cosmetic & Personal Care Actives: Potential ingredient in the synthesis of specialty peptides for advanced skincare formulations.
• Food & Nutraceutical Research: Investigated for use in specialized nutritional supplements and bioactive compounds.

Basic Information

Product Name	n-Acetyl-D-Leucine
CAS No.	19764-30-8
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	Ac-D-Leu-OH; N-Acetyl-D-leucine; D-2-Acetamido-4-methylpentanoic acid; (R)-2-Acetamido-4-methylpentanoic acid; D-Leucine, N-acetyl-; (R)-2-Acetamido-4-methylvaleric acid; N-Acetyl-(R)-leucine; NSC 3349
EINECS	243-300-9

Quality Control

Our n-Acetyl-D-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment. We support compliance with cGMP, ISO, and other relevant quality frameworks upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using a desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-Isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.