Description

Ac-Dl-Phe-Pna CAS NO 19746-42-0 is a protected amino acid derivative, specifically an N-acetylated phenylalanine p-nitroanilide. This compound serves as a critical synthetic intermediate and biochemical tool, valued for its role in peptide synthesis and enzyme substrate studies. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in proteomics and medicinal chemistry.

Application

• Protease & Enzyme Substrate: Used as a chromogenic or fluorogenic substrate for studying the activity and kinetics of proteolytic enzymes like chymotrypsin and subtilisin.
• Peptide Synthesis Intermediate: Acts as a key building block in solid-phase and solution-phase peptide synthesis, where the p-nitroanilide (Pna) group serves as a protective moiety.
• Biochemical Research: Employed in academic and industrial research for investigating enzyme mechanisms, inhibitor screening, and assay development.
• Pharmaceutical Development: Utilized in the discovery and development stages of new therapeutic agents, particularly those targeting protease pathways.
• Diagnostic Reagent Manufacturing: Incorporated into the formulation of diagnostic kits and reagents for clinical and research use.

Basic Information

Product Name	Ac-Dl-Phe-Pna
CAS No.	19746-42-0
Molecular Formula	C17H17N3O4
Molecular Weight	327.34 g/mol
Synonyms	N-Acetyl-DL-phenylalanine p-nitroanilide; Ac-Phe-pNA; N-Acetyl-DL-phenylalanine 4-nitroanilide; Acetyl-DL-phenylalanine p-nitroanilide; Chymotrypsin substrate; Protease substrate; N-Acetylphenylalanine p-nitroanilide; DL-N-Acetylphenylalanine 4-nitroanilide
EINECS	Contact for details

Quality Control

Our Ac-Dl-Phe-Pna is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.