Description

Ac-Leu-Pna CAS NO 19746-40-8 is a high-purity, protected amino acid derivative specifically designed for advanced peptide synthesis and biochemical research. This compound serves as a critical building block, enabling the precise construction of complex peptide sequences with controlled stereochemistry. It is an essential reagent for pharmaceutical R&D, proteomics studies, and the development of novel therapeutic agents and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key N-terminal protected leucine derivative for the sequential assembly of peptides.
• Pharmaceutical Intermediate: In the research and development of peptide-based active pharmaceutical ingredients (APIs) and prodrugs.
• Biochemical Research: For studying enzyme-substrate interactions, particularly with proteases, and in substrate activity profiling.
• Proteomics & Molecular Biology: Used in the synthesis of custom peptide standards, epitope mapping, and protein sequencing studies.
• Combinatorial Chemistry: As a building block in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: A fundamental reagent in university and institutional labs for teaching and investigating peptide chemistry principles.

Basic Information

Product Name	Ac-Leu-Pna
CAS No.	19746-40-8
Molecular Formula	C14H19N3O3
Molecular Weight	277.32 g/mol
Synonyms	N-Acetyl-L-leucine p-nitroanilide; Acetyl-Leucine p-Nitroanilide; L-Leucine, N-acetyl-, 4-nitroanilide; Ac-Leu-pNA; N-Acetyl-L-leu-p-nitroanilide; Substrate for leucine aminopeptidase; Ac-Leu-4-nitroanilide
EINECS	Contact for details

Quality Control

Every batch of Ac-Leu-Pna is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC purity, chiral purity, and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.