Description

Boc-Cys(Acm)-Oh is a protected cysteine derivative, a crucial building block in solid-phase peptide synthesis (SPPS). This compound matters because it provides orthogonal protection for the thiol group of cysteine, preventing unwanted side reactions during peptide chain assembly and enabling the formation of disulfide bridges under controlled conditions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries developing peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of cysteine residues into peptide sequences.
• Pharmaceutical Peptide Manufacturing: Used in the synthesis of therapeutic peptides requiring precise disulfide bond formation for correct folding and bioactivity.
• Bioconjugation and Protein Engineering: Serves as a precursor for introducing thiol-reactive handles or labels into biomolecules.
• Research & Development: Critical for academic and industrial R&D focused on peptide chemistry, structure-activity relationships (SAR), and novel drug discovery.
• Production of Cysteine-Containing Peptide Fragments: For the synthesis of peptide antigens, enzyme substrates, and hormone analogs.

Basic Information

Item	Detail
Product Name	Boc-Cys(Acm)-Oh
CAS No.	19746-37-3
Molecular Formula	C10H18N2O5S
Molecular Weight	278.33 g/mol
Synonyms	N-α-Boc-S-acetamidomethyl-L-cysteine; Boc-Cys(Acm)-OH; Boc-S-acetamidomethyl-L-cysteine; (2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(acetamidomethylsulfanyl)propanoic acid; BOC-CYS(ACM); Boc-L-Cys(Acm)-OH; tert-Butyloxycarbonyl-S-acetamidomethylcysteine; N-(tert-Butoxycarbonyl)-S-(acetamidomethyl)-L-cysteine
EINECS	Contact for details

Quality Control

Our Boc-Cys(Acm)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% L-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.